Chandra M, Frith C H
Experimental Pathology Department, American Cyanamid Company, Pearl River, NY 10965.
Toxicol Lett. 1992 Jun;61(1):67-74. doi: 10.1016/0378-4274(92)90064-q.
Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular carcinomas (5.7%), Harderian gland adenomas (2.9%), alveolar-bronchiolar carcinomas (2.5%), and testicular interstitial cell tumors (1.9%). In the females, the most frequently occurring neoplasms were lymphoreticular neoplasms (16.4%) followed by alveolar-bronchiolar adenomas (12.3%), uterine endometrial polyps (4.3%), uterine leiomyomas (3.5%), mammary adenocarcinomas (2.5%), hepatocellular adenomas (1.8%), hemangiomas (1.7%), Harderian adenomas (1.7%), alveolar-bronchiolar carcinomas (1.5%), and pituitary adenomas (1.1%). Tumors in other various organs were found at a low incidence.
对致癌性研究中使用的未经处理的对照CD-1小鼠（725只雄性和725只雌性）的自发性肿瘤进行了评估并制成表格。雄性小鼠中最常见的肿瘤是肺泡-支气管腺瘤（19.3%），其次是肝细胞腺瘤（11.0%）、淋巴网状肿瘤（6.8%）、肝细胞癌（5.7%）、哈德氏腺腺瘤（2.9%）、肺泡-支气管癌（2.5%）和睾丸间质细胞瘤（1.9%）。在雌性小鼠中，最常出现的肿瘤是淋巴网状肿瘤（16.4%），其次是肺泡-支气管腺瘤（12.3%）、子宫内膜息肉（4.3%）、子宫平滑肌瘤（3.5%）、乳腺腺癌（2.5%）、肝细胞腺瘤（1.8%）、血管瘤（1.7%）、哈德氏腺腺瘤（1.7%）、肺泡-支气管癌（1.5%）和垂体腺瘤（1.1%）。在其他各种器官中发现的肿瘤发生率较低。
