Rützler M, Zwiebel L J
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, VU Station B 351634, Nashville, TN 37235-3582, USA.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Sep;191(9):777-90. doi: 10.1007/s00359-005-0044-y. Epub 2005 Sep 13.
Insects have an enormous impact on global public health as disease vectors and as agricultural enablers as well as pests and olfaction is an important sensory input to their behavior. As such it is of great value to understand the interplay of the molecular components of the olfactory system which, in addition to fostering a better understanding of insect neurobiology, may ultimately aid in devising novel intervention strategies to reduce disease transmission or crop damage. Since the first discovery of odorant receptors in vertebrates over a decade ago, much of our view on how the insect olfactory system might work has been derived from observations made in vertebrates and other invertebrates, such as lobsters or nematodes. Together with the advantages of a wide range of genetic tools, the identification of the first insect odorant receptors in Drosophila melanogaster in 1999 paved the way for rapid progress in unraveling the question of how olfactory signal transduction and processing occurs in the fruitfly. This review intends to summarize much of this progress and to point out some areas where advances can be expected in the near future.
昆虫作为疾病传播媒介、农业促进者以及害虫，对全球公共卫生有着巨大影响，嗅觉是其行为的重要感官输入。因此，了解嗅觉系统分子成分之间的相互作用具有重要价值，这不仅有助于更好地理解昆虫神经生物学，最终还可能有助于设计新的干预策略，以减少疾病传播或作物损害。自从十多年前在脊椎动物中首次发现气味受体以来，我们对昆虫嗅觉系统工作方式的许多看法都源于在脊椎动物和其他无脊椎动物（如龙虾或线虫）中所做的观察。1999年在黑腹果蝇中首次鉴定出昆虫气味受体，再加上广泛的遗传工具的优势，为快速解开果蝇嗅觉信号转导和处理问题取得进展铺平了道路。本综述旨在总结这方面的许多进展，并指出在不久的将来有望取得进展的一些领域。
