Voogt Jason N, Blanch Harvey W
Chemical Engineering Department, University of California, Berkeley, California, USA.
Biotechnol Bioeng. 2005 Dec 5;92(5):532-40. doi: 10.1002/bit.20649.
Hydrogen-bonded networks composed of guanidinium (G) and 1,5-naphthalenedisulfonate (NDS) have been developed for the selective inclusion and separation of fatty acid esters based on their degree of unsaturation. Porous crystalline networks have been synthesized and include fatty acid esters during crystallization from both methanol and 2-methoxyethanol. Crystalline networks formed in methanol are selective for the inclusion of saturates in preference to polyunsaturated fatty acid methyl esters, but their applicability is limited by the competing inclusion of the solvent methanol. In 2-methoxyethanol, a three-component host structure is formed that provides 4.1 x 4.7 A2 pores which are also selective for saturated fatty acid ester inclusion. These networks do not suffer from the competing inclusion of the solvent 2-methoxyethanol as is the case with methanol, and thus complete removal of initial saturated fatty acid 2-methoxyethyl esters is possible. Binary selectivity experiments on mixtures of the 2-methoxyethyl esters of saturated stearic acid and the omega-3 fatty acid alpha-linolenic acid reveal that this three-component network structure provides nearly complete resolution of these two guests in the crystal and filtrate fractions. Separation of the 2-methoxyethyl esters of alpha-linolenic acid from the monounsaturated oleic acid is also possible, although with decreased efficiency in comparison to removal of the saturated fatty acid ester.
由胍（G）和1,5-萘二磺酸盐（NDS）组成的氢键网络已被开发用于根据脂肪酸酯的不饱和度进行选择性包合和分离。已合成多孔晶体网络，并且在从甲醇和2-甲氧基乙醇结晶过程中包含脂肪酸酯。在甲醇中形成的晶体网络优先选择性包合饱和脂肪酸酯而非多不饱和脂肪酸甲酯，但其适用性受到溶剂甲醇竞争性包合的限制。在2-甲氧基乙醇中，形成了一种三元主体结构，其提供4.1×4.7 Ų的孔，这些孔也对饱和脂肪酸酯的包合具有选择性。这些网络不会像甲醇那样受到溶剂2-甲氧基乙醇竞争性包合的影响，因此有可能完全除去初始的饱和脂肪酸2-甲氧基乙酯。对饱和硬脂酸和ω-3脂肪酸α-亚麻酸的2-甲氧基乙酯混合物进行的二元选择性实验表明，这种三元网络结构在晶体和滤液部分中对这两种客体提供了几乎完全的分离。从单不饱和油酸中分离α-亚麻酸的2-甲氧基乙酯也是可能的，尽管与除去饱和脂肪酸酯相比效率有所降低。
