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膳食脂肪酸调节肝脏CYP7α1表达的胆固醇诱导及胆汁酸生成。

Dietary fatty acids regulate cholesterol induction of liver CYP7alpha1 expression and bile acid production.

作者信息

Li Yan, Hou Meng Jun, Ma Jing, Tang Zhi Hong, Zhu Hui Lian, Ling Wen Hua

机构信息

Department of Clinical Nutrition, Sun Yat-sen University Northern Campus, Guangzhou, 510080, People's Republic of China.

出版信息

Lipids. 2005 May;40(5):455-62. doi: 10.1007/s11745-005-1404-2.

DOI:10.1007/s11745-005-1404-2
PMID:16094854
Abstract

In the present study we investigated the effects of dietary fats containing predominantly PUFA, monounsaturated FA (MUFA), or saturated FA (SFA) on lipid profile and liver cholesterol 7alpha-hydroxylase (CYP7alpha1) mRNA expression and bile acid production in C57BL/6J mice. The animals (n = 75) were randomly divided into five groups and fed a basic chow diet (AIN-93G) (BC diet), a chow diet with 1 g/100 g of cholesterol (Chol diet), a chow diet with 1 g/100 g of cholesterol and 14 g/100 g of safflower oil (Chol + PUFA diet), a chow diet with 1 g/100 g of cholesterol and olive oil (Chol + MUFA diet), or a chow diet with 1 g/100 g of cholesterol and myristic acid (Chol + SFA diet) for 6 wk. The results showed that the Chol + SFA diet decreased CYP7alpha1 gene expression and bile acid pool size, resulting in increased blood and liver cholesterol levels. Addition of PUFA and MUFA to a 1% cholesterol diet increased the bile acid pool production or bile acid excretion and simultaneously decreased liver cholesterol accumulation despite decreased CYP7alpha1 mRNA expression. The results indicate that the decreased bile acid pool size induced by the SFA diet is related to inhibition of the liver CYP7alpha1 gene expression, but an increased bile acid pool size and improved cholesterol homeostasis are disassociated from the liver CYP7alpha1 gene expression.

摘要

在本研究中，我们调查了主要含有多不饱和脂肪酸（PUFA）、单不饱和脂肪酸（MUFA）或饱和脂肪酸（SFA）的膳食脂肪对C57BL/6J小鼠血脂谱、肝脏胆固醇7α-羟化酶（CYP7α1）mRNA表达及胆汁酸生成的影响。将75只动物随机分为五组，分别给予基础饲料（AIN-93G）（BC饲料）、含1 g/100 g胆固醇的饲料（Chol饲料）、含1 g/100 g胆固醇和14 g/100 g红花油的饲料（Chol + PUFA饲料）、含1 g/100 g胆固醇和橄榄油的饲料（Chol + MUFA饲料）或含1 g/100 g胆固醇和肉豆蔻酸的饲料（Chol + SFA饲料），喂养6周。结果显示，Chol + SFA饲料降低了CYP7α1基因表达和胆汁酸池大小，导致血液和肝脏胆固醇水平升高。在1%胆固醇饲料中添加PUFA和MUFA可增加胆汁酸池生成或胆汁酸排泄，同时尽管CYP7α1 mRNA表达降低，但肝脏胆固醇蓄积减少。结果表明，SFA饲料诱导的胆汁酸池大小降低与肝脏CYP7α1基因表达受抑制有关，但胆汁酸池大小增加和胆固醇稳态改善与肝脏CYP7α1基因表达无关。

相似文献

[1]
Dietary fatty acids regulate cholesterol induction of liver CYP7alpha1 expression and bile acid production.

Lipids. 2005-5

[2]
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[3]
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[4]
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Br J Nutr. 2001-6

[5]
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Ann Nutr Metab. 1999

[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.

Proc Natl Acad Sci U S A. 2004-2-17

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J Biol Chem. 1957-5

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Biochem Biophys Res Commun. 2002-4-26

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J Biol Chem. 2002-6-7

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