米糠油饮食可改善链脲佐菌素/烟酰胺诱导的 2 型糖尿病大鼠的脂质异常和抑制高胰岛素血症反应。
A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes.
机构信息
Department of Tourism and Hospitality Management, Kainan University, Taoyuan 33857, Taiwan.
出版信息
J Clin Biochem Nutr. 2009 Jul;45(1):29-36. doi: 10.3164/jcbn.08-257. Epub 2009 Jun 30.
Abstract
The aim of this study was to determine the effects of rice bran oil (RBO) on lipid metabolism and insulin resistance in rats with streptozotocin/nicotinamide-induced type 2 diabetes mellitus (T2DM). Rats were divided into two groups: the control group (15% soybean oil, contains 0 g gamma-oryzanol and 0 g gamma-tocotrienol/150 g oil for 5 weeks) and the RBO group (15% RBO, contains 5.25 g gamma-oryzanol and 0.9 g gamma-tocotrienol/150 g oil for 5 weeks). Compared with the control group, the RBO group had a lower plasma nonesterified fatty acid concentration, ratio of total to high-density-lipoprotein cholesterol, hepatic cholesterol concentration, and area under the curve for insulin. The RBO group had a higher high-density-lipoprotein cholesterol concentration and greater excretion of fecal neutral sterols and bile acid than did the control group. RBO may improve lipid abnormalities, reduce the atherogenic index, and suppress the hyperinsulinemic response in rats with streptozotocin/nicotinamide-induced T2DM. In addition, RBO can lead to increased fecal neutral sterol and bile acid excretion.
摘要
本研究旨在探讨米糠油（RBO）对链脲佐菌素/烟酰胺诱导的 2 型糖尿病（T2DM）大鼠脂代谢和胰岛素抵抗的影响。大鼠分为两组：对照组（15%豆油，含 0 gγ-谷维素和 0 gγ-生育三烯酚/150 g 油，5 周）和 RBO 组（15%RBO，含 5.25 gγ-谷维素和 0.9 gγ-生育三烯酚/150 g 油，5 周）。与对照组相比，RBO 组的血浆非酯化脂肪酸浓度、总胆固醇与高密度脂蛋白胆固醇比值、肝胆固醇浓度和胰岛素曲线下面积较低。RBO 组的高密度脂蛋白胆固醇浓度较高，粪便中性固醇和胆汁酸排泄量也大于对照组。RBO 可能改善 T2DM 大鼠的脂代谢异常，降低致动脉粥样硬化指数，抑制高胰岛素血症反应。此外，RBO 可导致粪便中性固醇和胆汁酸排泄增加。
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