狼疮相关核糖核蛋白抗原内的表位扩展

Epitope spreading within lupus-associated ribonucleoprotein antigens.

作者信息

Deshmukh Umesh S, Bagavant Harini, Lewis Janet, Gaskin Felicia, Fu Shu Man

机构信息

Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA.

出版信息

Clin Immunol. 2005 Nov;117(2):112-20. doi: 10.1016/j.clim.2005.07.002. Epub 2005 Aug 10.

DOI:10.1016/j.clim.2005.07.002

PMID:16095971

Abstract

Autoantibodies reactive with several cellular antigens are present in the sera of patients with systemic lupus erythematosus. Polypeptides within the Ro-RNP complex and the snRNP complex are often targeted by these autoantibodies. One of the mechanisms responsible for their evolution is that of epitope spreading. Experimental animal model systems provide evidence for this. This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis.

摘要

系统性红斑狼疮患者血清中存在与多种细胞抗原发生反应的自身抗体。Ro-RNP复合物和snRNP复合物中的多肽常被这些自身抗体靶向。其演变的一种机制是表位扩展。实验动物模型系统为此提供了证据。本综述讨论了这些核糖核蛋白抗原中表位扩展的动物模型系统、表位扩展的机制及其与疾病发病机制的相关性。