Nowak A, Stemplewski R, Szeklicki R, Karolkiewicz J, Pilaczyńska-Szcześniak L, Osiński W
Department of Hygiene, University School of Physical Education, Królowej Jadwigi Str. 27/39, 61-871 Poznań, Poland.
Aging Male. 2005 Jun;8(2):75-80. doi: 10.1080/13685530500118477.
The purpose of the present study was to examine the serum levels of bone turnover markers and interleukin 1beta in healthy elderly men with different levels of habitual physical activity. The study was conducted on 40 healthy men aged between 65 and 85 years (mean 74.0 +/- 7.55 years). The study population was divided into two groups with respect to the level of physical activity: 22 less active subjects (energy expenditure related to physical activity below 1600 kcal per week) and 18 more active subjects (above 1600 kcal per week). To estimate the physical activity of the study population, weekly energy expenditure was measured in each subject with use of Caltrac accelerometer. In the blood serum levels of bone formation marker--osteocalcin and resorption marker--the C-terminal telopeptide of collagen I (ICTP), and interleukin-1beta were determined. Concentrations of osteocalcin and ICTP in less active subjects were significantly higher (by 3.62 ng/ml and by 1.21 mug/l respectively, p < 0.05), reflecting the higher bone turnover in comparison to values determined in more active subjects. Positive correlations between ICTP and osteocalcin levels (r = 0.5814 and r = 0.6526; p < 0.05), and between ICTP and IL-1beta (r = 0.5823 and r = 0.6040; p < 0.05) in less and more active men were found. On the ground of the presented study it can be concluded that the decreased bone turnover occurred in men with higher level of habitual physical activity. This study showed the relationship between serum level of IL-1beta and bone resorption but the habitual physical activity has no effect on this cytokine activity.
本研究的目的是检测不同习惯性身体活动水平的健康老年男性血清中骨转换标志物和白细胞介素1β的水平。该研究对40名年龄在65至85岁之间（平均74.0±7.55岁）的健康男性进行。根据身体活动水平，研究人群被分为两组：22名活动较少的受试者（与身体活动相关的能量消耗低于每周1600千卡）和18名活动较多的受试者（高于每周1600千卡）。为了评估研究人群的身体活动情况，使用Caltrac加速度计测量了每名受试者的每周能量消耗。测定了血清中骨形成标志物——骨钙素、骨吸收标志物——I型胶原C末端肽（ICTP）以及白细胞介素-1β的水平。活动较少的受试者中骨钙素和ICTP的浓度显著更高（分别高出3.62纳克/毫升和1.21微克/升，p<0.05），这反映出与活动较多的受试者相比，其骨转换率更高。在活动较少和较多的男性中，均发现ICTP与骨钙素水平之间呈正相关（r = 0.5814和r = 0.6526；p<0.05），以及ICTP与IL-1β之间呈正相关（r = 0.5823和r = 0.6040；p<0.05）。基于本研究可以得出结论，习惯性身体活动水平较高的男性骨转换率降低。本研究显示了IL-1β血清水平与骨吸收之间的关系，但习惯性身体活动对这种细胞因子活性没有影响。
