四氧嘧啶糖尿病大鼠的激肽原变化
Kininogen changes in the alloxan-diabetic rat.
作者信息
Reis M L, Paschoalato R, Serra C H
机构信息
Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
出版信息
Agents Actions Suppl. 1992;36:223-9.
PMID:1609646
Abstract
Ten-day alloxan diabetic rats showed substantial increases in plasma T-kininogen, high molecular and low molecular weight kininogens, as well as significant decreases in urinary levels of kallikrein. Changes in T-kininogen were also observed following turpentine inflammatory treatment. In the diabetic rat, inflammatory responses may contribute to T-kininogen increases.
摘要
患糖尿病10天的大鼠血浆T-激肽原、高分子量激肽原和低分子量激肽原显著增加，而尿中激肽释放酶水平显著降低。松节油炎症处理后也观察到T-激肽原的变化。在糖尿病大鼠中，炎症反应可能导致T-激肽原增加。
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