Sockalingam Sanjeev, Balderson Ken
University of Toronto, Toronto, Ontario, Canada.
Int Clin Psychopharmacol. 2005 Sep;20(5):289-90. doi: 10.1097/01.yic.0000170263.46008.54.
Recent evidence has demonstrated the efficacy of pegylated interferon-alpha (IFN-alpha) in treating hepatitis C virus infection. Neuropsychiatric complications commonly occur during the course of IFN treatment, with depressive symptoms usually appearing within the first 12 weeks. Few cases of the pegylated interferon-alpha-induced psychosis and depression have been reported compared to standard interferon-alpha therapy. We report the first case of a major depressive episode with psychotic features induced by pegylated IFN-alpha-2b and ribavirin in the last 2 weeks of therapy.
近期证据已证明聚乙二醇化干扰素-α（IFN-α）在治疗丙型肝炎病毒感染方面的疗效。神经精神并发症在IFN治疗过程中常见，抑郁症状通常在最初12周内出现。与标准干扰素-α治疗相比，聚乙二醇化干扰素-α诱发的精神病和抑郁的病例报道较少。我们报告了首例在治疗最后2周由聚乙二醇化IFN-α-2b和利巴韦林诱发的伴有精神病性特征的重度抑郁发作病例。
