Rothschild A M, Gomes E L, Rossi M A
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Agents Actions Suppl. 1992;36:78-86.
Mesentery mast cells have been observed to swell and to spontaneously return to their original size following feeding of 12-h fasted rats. This effect may be controlled by parasympathetic efferent nerve impulses, since it is inhibited by atropine. It was reproduced in vitro in isolated rat peritoneal fluid mast cells exposed for 30s to 10(-8)-10(-11) M acetylcholine. When examined under the electron microscope, mast cell average granule diameters had increased by 29% (p less than 0.001) following treatment. Swollen granules did not leave (exocytose) acetylcholine-treated mast cells. They gradually and spontaneously returned to their original size. This recovery only differed from that occurring in the fed rat by its greater speed.
在给禁食12小时的大鼠喂食后，观察到肠系膜肥大细胞会肿胀，并能自发恢复到原来的大小。这种效应可能受副交感传出神经冲动控制，因为它会被阿托品抑制。在体外，将分离的大鼠腹腔液肥大细胞暴露于10(-8)-10(-11)M乙酰胆碱30秒后，也重现了这种效应。在电子显微镜下检查时，经处理后的肥大细胞平均颗粒直径增加了29%（p<0.001）。肿胀的颗粒并未从经乙酰胆碱处理的肥大细胞中排出（胞吐）。它们会逐渐自发恢复到原来的大小。这种恢复与喂食大鼠体内发生的恢复情况的不同仅在于速度更快。
