Deisher T A
CV Biology, ZymoGenetics Inc, 1201 Eastwalk Avenue, East Seattle, WA 98102, USA.
IDrugs. 2000 Jun;3(6):649-53.
Current scientific dogma holds that cardiomyocyte stem cells do not exist in the adult mammalian heart, and furthermore, that there is little, if any, potential for the regeneration of damaged myocardium. In order to approach this topic, I have begun with a brief overview of advances in stem cell research in other organ systems, such as the bone marrow and the brain. Very recent progress in cardiac stem cell research is then discussed, which indicates that a cardiomyocyte progenitor cell contributes to cardiomyocyte replacement throughout life. This progenitor cell may reside in the heart itself, or derive from a circulating marrow stem cell.
当前的科学信条认为，成年哺乳动物心脏中不存在心肌干细胞，而且，受损心肌几乎没有再生潜力。为了探讨这个话题，我首先简要概述了其他器官系统，如骨髓和大脑的干细胞研究进展。然后讨论了心脏干细胞研究的最新进展，这表明心肌祖细胞在整个生命过程中都有助于心肌细胞的替代。这种祖细胞可能存在于心脏本身，或者来源于循环骨髓干细胞。
