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[双侧肾移植]

[Double kidney transplantation].

作者信息

Mongiat-Artus Pierre

机构信息

Service d'Urologie, Hôpital Saint-Louis, Paris, France.

出版信息

Prog Urol. 2005 Jun;15(3):441-6.

Abstract

The incidence of end-stage renal failure has been increasing for many years with a marked elevation of the mean age of kidney transplantation candidates. This situation contrasts with the shortage of kidney transplants. One solution, apart from the development of live donor kidney transplantation, is the use of so-called "borderline" cadavre kidneys. Double kidney transplantation is performed in the context of enlargement of the number of "borderline" donors. A review of the medical literature reporting the experience acquired in double kidney transplantation demonstrates a marked heterogeneity of donor selection criteria between the various teams. Recipients are generally selected from among the oldest patients waiting for transplantation. Double kidney transplantation is not associated with any excess mortality and graft survival and graft function are perfectly satisfactory, ensuring a serum creatinine close to 200 micromol/l at 3 years. These results are obtained at the price of low morbidity. Wound complications are not more frequent than after single kidney transplantation. With the exception of one team, vascular complications are not more frequent, but are even more serious than for single kidney transplantation. Ureteric strictures and fistulas are observed more frequently when the two ureters are reimplanted into a common conduit in the case of homolateral transplantation of the two kidneys. Overall, double kidney transplantation has allowed a 10% increase in the recruitment of "borderline" kidneys by all teams with satisfactory functional results and low morbidity. However, donor and recipient selection criteria for double kidney transplantation need to be more precisely defined to avoid depriving elderly patients of transplantation and to avoid using two kidneys in the same recipient when one kidney would have ensured a satisfactory functional result, Two ongoing French studies will probably allow progress in this direction by evaluating the feasibility and benefits of this technique in France.

摘要

终末期肾衰竭的发病率多年来一直在上升,肾移植候选者的平均年龄显著提高。这种情况与肾移植供体短缺形成对比。除了发展活体供肾移植外,一种解决办法是使用所谓的“边缘性”尸体肾。在“边缘性”供体数量增加的情况下进行双肾移植。对报道双肾移植经验的医学文献进行回顾发现,各团队之间的供体选择标准存在显著差异。受者通常从等待移植的老年患者中挑选。双肾移植与任何额外的死亡率无关,移植肾存活和移植肾功能非常令人满意,3年时血清肌酐接近200微摩尔/升。这些结果是以低发病率为代价获得的。伤口并发症并不比单肾移植后更频繁。除了一个团队外,血管并发症并不更频繁,但比单肾移植时更严重。当两个肾脏同侧移植且两条输尿管重新植入一个共同管道时,输尿管狭窄和瘘管的发生率更高。总体而言,双肾移植使所有团队“边缘性”肾脏的招募增加了10%,功能结果令人满意且发病率低。然而,双肾移植的供体和受者选择标准需要更精确地界定,以避免剥夺老年患者的移植机会,并避免在一个肾脏就能确保功能结果满意的情况下在同一受者中使用两个肾脏。两项正在进行的法国研究可能会通过评估该技术在法国的可行性和益处,在这个方向上取得进展。

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