Tabayashi Koichi
Department of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kyobu Geka. 2005 Jul;58(8 Suppl):632-5.
Organ hypofunction by aging exaggerate damages, which are caused by cardiopulmonary bypass. The main cause of organ dysfunction after cardiopulmonary bypass is systemic inflammatory response, which is induced by continuous interaction of blood with unphysiologic surfaces, shear stress to blood cells, and incorporation of abnormal substances. To reduce the postoperative complications after cardiovascular surgery in elderly patients, intensive and careful control of cardiopulmonary bypass and several kinds of anti-inflammatory treatment are important.
衰老导致的器官功能减退会加剧体外循环所造成的损害。体外循环后器官功能障碍的主要原因是全身炎症反应，它是由血液与非生理表面的持续相互作用、对血细胞的剪切应力以及异常物质的混入所诱发的。为减少老年患者心血管手术后的并发症，对体外循环进行严格细致的控制以及多种抗炎治疗至关重要。
