Huang Xi-ru, Cai Yong-mei, Tai Yan, Cao Dong
Department of Analytical Chemistry, the School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Apr;25(4):620-3.
The present paper is to study ratio spectrophotometry for its application to the assay of compound pharmacy preparations. According to the feature of ratio spectra, the wavelength pair was selected at the peak point or valley point of ratio spectra to establish ratio spectrophotometry for the determination of Co-Chlorzoxazone tablet and injection of caffeine and sodium benzoate. The average recoveries and relative standard deviations for Chlorzoxazone and paracetamol were 100.0% and 1.28%, and 100.0% and 0.84%, respectively; the average recoveries and relative standard deviations for caffeine and sodium benzoate were 99.98% and 0.70%, and 99.91% and 0.78%, respectively. It is concluded that as long as the ratio spectra exhibit at least one peak and one valley, the results are satisfactory.
本文旨在研究比值分光光度法在复方药物制剂分析中的应用。根据比值光谱的特征，在比值光谱的峰点或谷点处选择波长对，建立了测定氯唑沙宗片以及咖啡因和苯甲酸钠注射液的比值分光光度法。氯唑沙宗和平痛新的平均回收率及相对标准偏差分别为100.0%和1.28%，以及100.0%和0.84%；咖啡因和苯甲酸钠的平均回收率及相对标准偏差分别为99.98%和0.70%，以及99.91%和0.78%。结果表明，只要比值光谱至少呈现一个峰和一个谷，结果就是令人满意的。
