Xie Feng, Tsutsui Jeane M, McGrain Anna C, Demaria Anthony, Cotter Bruno, Becher Harald, Lebleu Curtis, Labovitz Arthur, Picard Michael H, O'Leary Edward L, Porter Thomas R
University of Nebraska Medical Center, Omaha, Nebraska, USA.
Am J Cardiol. 2005 Aug 15;96(4):506-11. doi: 10.1016/j.amjcard.2005.04.010.
In a pilot study of 27 patients, those who presented with chest pain underwent 2 dobutamine stress echocardiographic studies, 1 with high mechanical index harmonic imaging to analyze wall motion without contrast and 1 with real-time low mechanical index perfusion imaging with intravenous Optison to assess myocardial perfusion and wall motion. All patients then underwent quantitative coronary angiography. Two independent reviewers demonstrated an improvement in sensitivity when analyzing myocardial perfusion. In the 21 patients who had significant coronary stenoses, 14 had abnormal myocardial perfusion detected at peak stress and 7 had abnormal wall motion detected by standard dobutamine stress echocardiography. There was decreased specificity with perfusion imaging by 1 reviewer. The addition of real-time perfusion imaging after intravenous contrast during dobutamine stress echocardiography has the potential to improve detection of coronary artery disease.
在一项针对27名患者的初步研究中，出现胸痛症状的患者接受了2次多巴酚丁胺负荷超声心动图检查，1次采用高机械指数谐波成像以在无造影剂情况下分析室壁运动，另1次采用静脉注射Optison进行实时低机械指数灌注成像以评估心肌灌注和室壁运动。所有患者随后均接受了定量冠状动脉造影。两名独立的评估者在分析心肌灌注时显示出敏感性有所提高。在21例存在明显冠状动脉狭窄的患者中，14例在负荷峰值时检测到心肌灌注异常，7例通过标准多巴酚丁胺负荷超声心动图检测到室壁运动异常。有1名评估者发现灌注成像的特异性有所降低。在多巴酚丁胺负荷超声心动图检查期间静脉注射造影剂后增加实时灌注成像，有可能提高对冠状动脉疾病的检测能力。
