早期阴茎癌转移至脑部：病例报告及文献综述

Early-stage penile carcinoma metastasizing to brain: case report and literature review.

作者信息

Lutterbach Johannes, Pagenstecher Axel, Weyerbrock Astrid, Schultze-Seemann Wolfgang, Waller Cornelius Florian

机构信息

Department of Radiation Oncology, Cancer Center Freiburg, Freiburg, Germany.

出版信息

Urology. 2005 Aug;66(2):432. doi: 10.1016/j.urology.2005.02.011.

DOI:10.1016/j.urology.2005.02.011

PMID:16098372

Abstract

Early-stage penile squamous cell carcinoma with subsequent distant metastases is rare. We report a case of a 35-year-old man with Stage pT1pN0 penile squamous cell carcinoma who underwent circumcision and bilateral inguinal lymphadenectomy. Further in the disease course, the patient developed metastases in the kidney, adrenal gland, retroperitoneal lymph nodes, lung, and brain. He underwent multiple resections, whole brain radiotherapy, and several chemotherapy regimens. All these metastases were histologically confirmed. Forty months after the first diagnosis, the patient died of thromboembolic complications. This case was unique because of the unusual pattern of dissemination, especially the spread to the brain.

摘要

早期阴茎鳞状细胞癌伴随后期远处转移较为罕见。我们报告一例35岁男性患者，患有pT1pN0期阴茎鳞状细胞癌，接受了包皮环切术和双侧腹股沟淋巴结清扫术。在疾病进程中，患者出现了肾脏、肾上腺、腹膜后淋巴结、肺和脑转移。他接受了多次切除术、全脑放疗和几种化疗方案。所有这些转移均经组织学证实。首次诊断后40个月，患者死于血栓栓塞并发症。该病例独特之处在于其不寻常的播散模式，尤其是脑转移。