Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
J Neurooncol. 2010 Jul;98(3):417-9. doi: 10.1007/s11060-009-0087-y. Epub 2009 Dec 15.
We report herein a clinical case of a patient with meningeal carcinomatosis from penile squamous cell carcinoma. A 68-year-old man presented with mental changes, headaches, and unstable gait. Examinations revealed brain metastases and infiltration of the leptomeninges and subarachnoid space by carcinoma cells. Only 11 months earlier the patient had been diagnosed with penile squamous cell carcinoma of poor differentiation and had underwent subtotal penectomy and adjuvant chemotherapy and radiation. Infiltration of the central nervous system with penile cancer is extremely rare, and only five cases with brain metastases have been described to date. This is the first report of a patient with penile cancer spread to the leptomeninges.
我们在此报告一例阴茎鳞状细胞癌脑膜转移导致脑膜癌病的临床病例。一名 68 岁男性因精神改变、头痛和步态不稳就诊。检查发现脑转移和软脑膜及蛛网膜下腔的癌细胞浸润。仅在 11 个月前，该患者被诊断为分化差的阴茎鳞状细胞癌，并接受了阴茎部分切除术和辅助化疗及放疗。阴茎癌侵犯中枢神经系统极为罕见，迄今为止仅描述了 5 例脑转移病例。这是首例阴茎癌播散至软脑膜的患者报告。
