Fischer Russell J
Woodland Research Institute, 17 Woodland Rd, Bernardsville, NJ 07924, USA.
Comput Biol Med. 2006 Nov;36(11):1204-15. doi: 10.1016/j.compbiomed.2005.05.006. Epub 2005 Aug 10.
A new measure of heart rate variability is proposed to investigate the interaction of the sino-atrial (SA) and atrio-ventricular (AV) pacemakers. Using electrocardiogram (ECG) fiduciary markers corresponding to the depolarization time of the SA and AV pacemakers, the variability of SA and AV depolarization rate is jointly analyzed by spectral analysis. The result of this joint analysis provides evidence of a distinct pattern of interaction between the SA and AV nodes prior to the onset of paroxysmal atrial fibrillation (PAF): frequency entrainment between the primary and secondary pacemakers of the heart, occurring at the respiratory frequency. We propose a measure of this entrainment as a diagnostic indicator for PAF, and compare it to standard diagnostic measures. The entrainment measure is found to have greater diagnostic power than five other common ECG-derived measures.
提出了一种新的心率变异性测量方法，以研究窦房（SA）和房室（AV）起搏器之间的相互作用。利用与SA和AV起搏器去极化时间相对应的心电图（ECG）基准标记，通过频谱分析联合分析SA和AV去极化率的变异性。这种联合分析的结果提供了阵发性心房颤动（PAF）发作前SA和AV结之间独特相互作用模式的证据：心脏初级和次级起搏器之间的频率夹带，发生在呼吸频率。我们提出将这种夹带测量作为PAF的诊断指标，并将其与标准诊断方法进行比较。发现夹带测量比其他五种常见的心电图衍生测量方法具有更强的诊断能力。
