围产期母体接触印防己毒素：对雌性大鼠后代性行为的影响。

Perinatal maternal exposure to picrotoxin: effects on sexual behavior in female rat offspring.

作者信息

Teodorov E, Moraes A P, Felicio L F, Varolli F M, Bernardi M M

机构信息

Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, CEP:05508-900, São Paulo, Brazil.

出版信息

Pharmacol Biochem Behav. 2005 Aug;81(4):935-42. doi: 10.1016/j.pbb.2005.07.002.

DOI:10.1016/j.pbb.2005.07.002

PMID:16098570

Abstract

A previous study in our laboratory showed that perinatal maternal picrotoxin exposure (0.75 mg/kg) in rats improved heterosexual behavior in male offspring. In the present study, we examined the effects of this maternal treatment on sexual behavior in the female offspring. The dams received 0.75 mg/kg picrotoxin treatment (PT) once a day on the 18th and 21st day of pregnancy, 2 h after parturition and once a day during the first 4 days of lactation. The results showed that (1) at birth, the body weight and anogenital distance were not modified by treatment; (2) female sexual behavior was improved in experimental animals. These results demonstrate that perinatal picrotoxin exposure improves adult sexual behavior in female rat offspring as suggested by increase in the lordosis quotient.

摘要

我们实验室之前的一项研究表明，围产期母鼠接触印防己毒素（0.75毫克/千克）可改善雄性后代的异性性行为。在本研究中，我们检测了这种母体处理对雌性后代性行为的影响。孕鼠在妊娠第18天和第21天、分娩后2小时以及哺乳期的前4天每天接受一次0.75毫克/千克印防己毒素处理（PT）。结果显示：（1）出生时，处理并未改变体重和肛门生殖距；（2）实验动物的雌性性行为得到改善。这些结果表明，围产期接触印防己毒素可改善雌性大鼠后代的成年性行为，这由脊柱前凸商数的增加所表明。