Neziroglu F, Anemone R, Yaryura-Tobias J A
Bio-Behavioral Psychiatry, Great Neck, NY 11021.
Am J Psychiatry. 1992 Jul;149(7):947-50. doi: 10.1176/ajp.149.7.947.
Although the role of pregnancy and childbirth in postpartum psychosis and depression has been studied, the association between pregnancy and obsessive-compulsive disorder has not been specifically addressed. The authors evaluated the role of pregnancy in the onset of obsessive-compulsive disorder.
Female patients with obsessive-compulsive disorder (N = 106) completed a questionnaire assessing age at onset of symptoms, marital status, number of children, age at each pregnancy, and life events associated with the onset of obsessive-compulsive disorder.
Of the 106 women, 42 were childless and 59 had at least one child each; five others were also childless but had had abortions (N = 4) or a miscarriage (N = 1). Of the 42 women without children, 12 (28.6%) had first experienced obsessive-compulsive symptoms between the ages of 13 and 15 years, but there were two peaks of onset for the women with children: ages 22-24 and 29-32 years. Of the 59 patients with children, 23 (39.0%) had experienced symptom onset during pregnancy; this was the first pregnancy for 12, the second pregnancy for eight, and the third pregnancy for three. Four of the five women who had had abortions or a miscarriage had experienced the onset or an exacerbation of obsessive-compulsive symptoms during pregnancy.
The association between pregnancy and the onset of obsessive-compulsive symptoms in these female patients highlights the need for further research on psychological and biological factors associated with pregnancy and obsessive-compulsive disorder.
尽管妊娠和分娩在产后精神病及抑郁症中的作用已得到研究，但妊娠与强迫症之间的关联尚未得到专门探讨。作者评估了妊娠在强迫症发病中的作用。
106名患有强迫症的女性患者完成了一份问卷，该问卷评估了症状出现时的年龄、婚姻状况、子女数量、每次怀孕时的年龄以及与强迫症发病相关的生活事件。
106名女性中，42名无子女，59名至少各有一个孩子；另外5名也无子女，但有过堕胎经历（4例）或流产经历（1例）。在42名无子女的女性中，12名（28.6%）在13至15岁之间首次出现强迫症状，但有子女的女性发病有两个高峰：22至24岁和29至32岁。在59名有子女的患者中，23名（39.0%）在怀孕期间出现症状；其中12名是首次怀孕，8名是第二次怀孕，3名是第三次怀孕。5名有堕胎或流产经历的女性中有4名在怀孕期间出现或加重了强迫症状。
这些女性患者中妊娠与强迫症状发作之间的关联凸显了对与妊娠和强迫症相关的心理及生物学因素进行进一步研究的必要性。
