上半阴道切除术治疗阴道上皮内瘤变
Upper vaginectomy for the treatment of vaginal intraepithelial neoplasia.
作者信息
Indermaur Megan D, Martino Martin A, Fiorica James V, Roberts William S, Hoffman Mitchel S
机构信息
Department of Gynecology Onclogy, University of South Florida, Tampa, FL, USA.
出版信息
Am J Obstet Gynecol. 2005 Aug;193(2):577-80; discussion 580-1. doi: 10.1016/j.ajog.2005.03.055.
OBJECTIVE
The purpose of this study was to evaluate the use of upper vaginectomy for the treatment of vaginal intraepithelial neoplasia (VAIN).
STUDY DESIGN
We conducted a retrospective review. Between August 1, 1985 and April 30, 2004, 105 patients were identified who had undergone upper vaginectomy for VAIN.
RESULTS
Thirty-six patients had previously been treated for VAIN. Mean operative time and estimated blood loss were 55 minutes and 113 mL, respectively. Ten percent had intraoperative complications. Twenty-three (22%) patients had negative findings on final pathologic examination, and invasive cancer was found in 13 (12%) patients. Four patients had postoperative complications. Follow-up was available in 52 patients; 46 (88%) remain without recurrence at a mean follow-up of 25 months.
CONCLUSION
In our patients, upper vaginectomy was efficacious for the treatment of VAIN. The procedure led to the diagnosis of occult invasive cancer in 12% of these women.
目的
本研究旨在评估上阴道切除术治疗阴道上皮内瘤变（VAIN）的应用效果。
研究设计
我们进行了一项回顾性研究。在1985年8月1日至2004年4月30日期间，确定了105例因VAIN接受上阴道切除术的患者。
结果
36例患者此前曾接受过VAIN治疗。平均手术时间和估计失血量分别为55分钟和113毫升。10%的患者有术中并发症。23例（22%）患者最终病理检查结果为阴性，13例（12%）患者发现浸润性癌。4例患者有术后并发症。52例患者有随访资料；平均随访25个月时，46例（88%）无复发。
结论
在我们的患者中，上阴道切除术治疗VAIN有效。该手术使12%的此类女性被诊断出隐匿性浸润性癌。
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