Adamec Robert E, Blundell Jacqueline, Burton Paul
Dept. of Psychology, Memorial University, 232 Elizabeth Ave., St. John's, Nl, Canada.
Neurosci Biobehav Rev. 2005;29(8):1225-41. doi: 10.1016/j.neubiorev.2005.05.007. Epub 2005 Aug 15.
This paper reviews recent work which points to critical neural circuitry involved in lasting changes in anxiety like behavior following unprotected exposure of rats to cats (predator stress). Predator stress may increase anxiety like behavior in a variety of behavioral tests including: elevated plus maze, light dark box, acoustic startle, and social interaction. Studies of neural transmission in two limbic pathways, combined with path and covariance analysis relating physiology to behavior, suggest long term potentiation like changes in one or both of these pathways in the right hemisphere accounts for stress induced changes in all behaviors changed by predator stress except light dark box and social interaction. Findings will be discussed within the context of what is known about neural substrates activated by predator odor.
本文回顾了近期的研究工作，这些工作指出了在大鼠无保护地暴露于猫（捕食者应激）后，与焦虑样行为的持久变化相关的关键神经回路。捕食者应激可能会在多种行为测试中增加焦虑样行为，包括：高架十字迷宫、明暗箱、听觉惊吓和社交互动。对两条边缘通路神经传递的研究，结合将生理学与行为相关联的路径和协方差分析，表明右半球中这两条通路中的一条或两条发生的类似长时程增强的变化，解释了捕食者应激引起的所有行为变化中除明暗箱和社交互动之外的应激诱导变化。将在已知捕食者气味激活的神经基质的背景下讨论这些发现。
