Allen Richard P, Dean Terry, Earley Christopher J
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
Sleep Med. 2005 Sep;6(5):429-34. doi: 10.1016/j.sleep.2005.05.010.
The diagnostic criteria for restless legs syndrome (RLS) indicate that both time-of-day and rest effects induce or aggravate symptoms. Periodic limb movements while awake (PLMW) provide an objective motor sign of RLS that can be measured during an awake suggested immobilization test (SIT). This study uses the SIT at different times of the day and analyzes time-of-day and duration-of-rest effects and their interaction on the PLMW.
Twenty-eight RLS patients who were not on medications had SIT tests at 10 pm, 8 am and 4 pm on two consecutive days. PLMW for each 20-min period were analyzed for time-of-day and rest effects and their interaction. PLMW increase from the first to last 20-min SIT period assessed the rest-effects.
Significant effects were found for rest, time-of-day and rest-time-of-day interaction. The rest-effect increased most from morning to afternoon while total PLMW increased more from afternoon to night. Males compared to females had significantly more PLMW and a larger rest-effect change with time-of-day.
Rest and time-of-day effects and their interaction all increase RLS symptoms. PLMW increase with rest may provide a sensitive measure of symptom severity.
不宁腿综合征（RLS）的诊断标准表明，一天中的时间以及休息效应均可诱发或加重症状。清醒时周期性肢体运动（PLMW）为RLS提供了一种客观的运动体征，可在清醒状态下的建议固定试验（SIT）期间进行测量。本研究在一天中的不同时间进行SIT试验，并分析一天中的时间和休息时长效应及其对PLMW的相互作用。
28例未服用药物的RLS患者在连续两天的晚上10点、上午8点和下午4点进行SIT试验。对每20分钟时间段的PLMW进行一天中的时间和休息效应及其相互作用的分析。从第一个到最后一个20分钟SIT时间段的PLMW增加情况评估休息效应。
发现休息、一天中的时间以及休息-一天中的时间相互作用有显著效应。休息效应从上午到下午增加最多，而总的PLMW从下午到晚上增加更多。与女性相比，男性的PLMW显著更多，且休息效应随一天中的时间变化更大。
休息和一天中的时间效应及其相互作用均会加重RLS症状。PLMW随休息增加可能提供了一种症状严重程度的敏感测量方法。
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