立体定向放射外科作为新诊断的多发（3 - 6个）颅内转移瘤治疗的主要选择的作用。

Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases.

作者信息

Jawahar Ajay, Shaya Mark, Campbell Peter, Ampil Federico, Willis Brian K, Smith Donald, Nanda Anil

机构信息

Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA.

出版信息

Surg Neurol. 2005 Sep;64(3):207-12. doi: 10.1016/j.surneu.2005.04.003.

DOI:10.1016/j.surneu.2005.04.003

PMID:16099246

Abstract

OBJECTIVE

The objective of this study was to assess the role of stereotactic radiosurgery in the management of newly diagnosed multiple intracranial metastases from known primary cancer locations.

METHODS

Fifty (29 women and 21 men) patients received radiosurgery for newly diagnosed 3 or more metastatic brain tumors. Their mean age was 53 years. Lung cancer was the most common primary cancer (66%).

RESULTS

Arrest in the growth of irradiated tumors was achieved in 41 (82%) patients. Eight patients (16%) required further intervention for tumors in other brain locations. Mean survival after diagnosis of brain disease was 12 months and the brain disease-controlled period was 19 months. The period of brain disease control prolonged (P=.03) with decreasing tumor volumes (<10 mL). Control of treated tumors positively affected survival after diagnosis of brain disease (P=.0001).

CONCLUSION

Radiosurgery as an adjuvant improves survival in patients with cancer who have newly diagnosed multiple intracranial metastases by arresting the growth of tumors.

摘要

目的

本研究的目的是评估立体定向放射外科在治疗已知原发癌部位新诊断的多发颅内转移瘤中的作用。

方法

50例（29例女性和21例男性）患者接受了放射外科治疗，用于新诊断的3个或更多转移性脑肿瘤。他们的平均年龄为53岁。肺癌是最常见的原发癌（66%）。

结果

41例（82%）患者的照射肿瘤生长得到控制。8例（16%）患者因其他脑部位的肿瘤需要进一步干预。脑疾病诊断后的平均生存期为12个月，脑疾病控制期为19个月。随着肿瘤体积减小（<10 mL），脑疾病控制期延长（P = 0.03）。治疗肿瘤的控制对脑疾病诊断后的生存期有积极影响（P = 0.0001）。