Sadick Haneen, Bergler Wolfgang F, Oulmi-Kagermann Jasmina, Naim Ramin, Sadick Maliha, Hörmann Karl, Riedel Frank
Department of Otolaryngology, Head and Neck Surgery, University Hospital Manheim, Germany.
Arch Med Res. 2005 Sep-Oct;36(5):468-73. doi: 10.1016/j.arcmed.2005.03.037.
The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT).
Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a period of 12 months. Written consent was obtained from each patient, allowing biopsy specimens of the nasal mucosa to be taken prior to and 3, 6 and 12 months after estriol application.
Metaplastic change of the nasal mucosa was observed 6 months after topical estriol application. The former ciliated columnar epithelium changed into a keratinizing squamous epithelium. The effect was reversible after discontinuation of estriol application.
For the first time, we could outline the effect of topical estriol on the nasal mucosa. These histomorphological findings, and the fact that estriol is a low-potency metabolite of estradiol, make estriol a valuable agent in the treatment of HHT patients.
本研究旨在通过光学显微镜和电子显微镜评估局部应用雌三醇对遗传性出血性毛细血管扩张症（HHT）患者鼻黏膜的影响。
12例患者被指导每日两次应用0.1%雌三醇鼻软膏，为期12个月。获得每位患者的书面同意，允许在应用雌三醇前以及应用后3、6和12个月采集鼻黏膜活检标本。
局部应用雌三醇6个月后观察到鼻黏膜化生改变。先前的纤毛柱状上皮转变为角化鳞状上皮。停用雌三醇后，这种效应是可逆的。
我们首次能够概述局部应用雌三醇对鼻黏膜的影响。这些组织形态学发现，以及雌三醇是雌二醇低活性代谢产物这一事实，使雌三醇成为治疗HHT患者的一种有价值的药物。
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