横向相互作用机制对人类视网膜电图的贡献可以用双频方法进行研究。

Contributions from lateral interaction mechanisms to the human ERG can be studied with a two-frequency method.

作者信息

Meigen Th, Prüfer R, Reime S, Friedrich A

机构信息

Department of Ophthalmology, University of Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany.

出版信息

Vision Res. 2005 Oct;45(22):2862-76. doi: 10.1016/j.visres.2005.06.025.

DOI:10.1016/j.visres.2005.06.025

PMID:16099490

Abstract

We present a two-frequency method to investigate lateral interaction components (liERGs) in the human electroretinogram. Adjacent half cycles of sinusoidal gratings were modulated sinusoidally with different temporal frequencies f1 and f2. The liERGs were defined by the Fourier components at the intermodulation frequencies /f1 - f2/ and f1 + f2 which indicate nonlinear interactions between the half cycles. Significant liERGs were found in all subjects with a monotonic increase of the liERG magnitude in the spatial frequency range from f(s)=0.07 to 2.4 cpd. When /f1 - f2/ was below 5 Hz, liERGs were masked by noise intrusions. In a control experiment we demonstrated that the liERGs were not evoked by stray light artifacts. The liERGs may help to further differentiate the responses that are evoked by patterned stimuli within the retina.

摘要

我们提出了一种双频方法来研究人类视网膜电图中的横向相互作用成分（liERGs）。正弦光栅的相邻半周期以不同的时间频率f1和f2进行正弦调制。liERGs由互调频率/f1 - f2/和f1 + f2处的傅里叶分量定义，这些频率表示半周期之间的非线性相互作用。在所有受试者中均发现了显著的liERGs，其在空间频率范围从f(s)=0.07至2.4 cpd内，liERG幅度呈单调增加。当/f1 - f2/低于5 Hz时，liERGs被噪声干扰所掩盖。在一项对照实验中，我们证明liERGs不是由杂散光伪影诱发的。liERGs可能有助于进一步区分视网膜内图案刺激所诱发的反应。