Gavaghan D J, Simpson A C, Lloyd S, Mac Randal D F, Boyd D R S
Oxford University Computing Laboratory, Oxford, UK.
Philos Trans A Math Phys Eng Sci. 2005 Aug 15;363(1833):1829-41. doi: 10.1098/rsta.2005.1610.
This paper discusses the scientific rationale behind the e-Science project, Integrative Biology, which is developing mathematical modelling tools, HPC-enabled simulations and an underpinning Grid infrastructure to provide an integrative approach to the modelling of complex biological systems. The project is focusing on two key applications to validate the approach: the modelling of heart disease and cancer, which together are responsible for over 60% of deaths in the United Kingdom. This paper provides an overview of the project, describes the initial prototype architecture and discusses the long-term scientific aims.
本文讨论了电子科学项目“整合生物学”背后的科学原理，该项目正在开发数学建模工具、高性能计算支持的模拟以及基础网格基础设施，以提供一种对复杂生物系统进行建模的综合方法。该项目专注于两个关键应用来验证该方法：心脏病和癌症的建模，这两种疾病加起来导致了英国超过60%的死亡。本文概述了该项目，描述了初始原型架构，并讨论了长期科学目标。
