支气管相关淋巴组织（BALT）中的多巴胺神经纤维及相关受体。

Dopamine nerve fibres and related receptors in bronchus-associated lymphoid tissue (BALT).

作者信息

Cavallotti C, Artico M, Franchitto S, Tranquilli Leali F M

机构信息

Department of Cardiovascular and Respiratory Sciences (Section of Anatomy), University of Rome La Sapienza, Rome, Italy.

出版信息

Ital J Anat Embryol. 2005;110(2 Suppl 1):25-30.

PMID:16101017

Abstract

Age-related changes of the dopamine nerve fibres of bronchus associated lymphoid tissue (BALT) were investigated in male Wistar rats of 3 months (young), and 24 months (old/aged). Dopamine histofluorescence techniques have been used, associated with image analysis for the detection of dopamine nerve fibres. In young rats, white, fluorescent nerve fibres supply BALT. This tissue is innervated by a delicate network of nerve fibres rich in varicosities. In old rats these fluorescent nerve fibres are strongly reduced. Moreover, dopamine D1a and D1b receptors were stained using fluorescent monoclonal antibodies. The BALT of young rats possesses a higher number of D1a and D1b receptors, while, in the old rats, these receptors are strongly reduced. The possible significance of reduced dopamine neurotransmission in BALT of aged rats is discussed.

摘要

在3个月大（年轻）和24个月大（年老）的雄性Wistar大鼠中，研究了支气管相关淋巴组织（BALT）中多巴胺神经纤维的年龄相关变化。采用多巴胺组织荧光技术，并结合图像分析来检测多巴胺神经纤维。在年轻大鼠中，白色荧光神经纤维为BALT提供支配。该组织由富含曲张体的精细神经纤维网络支配。在年老大鼠中，这些荧光神经纤维显著减少。此外，使用荧光单克隆抗体对多巴胺D1a和D1b受体进行染色。年轻大鼠的BALT拥有更多数量的D1a和D1b受体，而在年老大鼠中，这些受体显著减少。本文讨论了老年大鼠BALT中多巴胺神经传递减少的可能意义。