Binding of recombinant mistletoe lectin (aviscumine) to resected human adenocarcinoma of the lung.
作者信息
Blonski Katharina, Schumacher Udo, Burkholder Iris, Edler Lutz, Nikbakht Haleh, Boeters Ina, Peters Anja, Kugler Christian, Horny Hans-Peter, Langer Martin, Wilhelm-Ogunbiyi Karin, Witthohn Klaus, Laack Eckart
机构信息
Department of Anatomy II: Experimental Morphology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
出版信息
Anticancer Res. 2005 Sep-Oct;25(5):3303-7.
BACKGROUND
Lectins, carbohydrate proteins, bind to glycoconjugates of all mammalian cells, including cancer cells. Aberrant glycosylation, detected by lectin histochemistry, can predict outcome in some tumour entities. One such lectin is aviscumine (recombinant mistletoe lectin). Aviscumine has cytotoxic effects and can therefore be used as anti-tumour therapy.
MATERIALS AND METHODS
Lectin histochemistry with aviscumine was performed on primary tumour sections from resected adenocarcinoma of the lung. Staining results were then correlated with the clinical course of the patients.
RESULTS
Most of the adenocarcinomas (92.5%) bound aviscumine. Kaplan-Meier analysis revealed no correlation between aviscumine binding and progression-free survival or overall survival.
CONCLUSION
These results suggest that for the selected group of patients with adenocarcinoma of the lung aviscumine binding activity can not serve as a prognostic factor. More strikingly, however, aviscumine binds to malignant cells in 92.5% of the patients. This is an indicator for the use of aviscumine as a possible target for tumour therapy.
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