日本临床局限性前列腺癌的根治性外照射放疗：1996 - 1998年与1999 - 2001年护理流程调查模式的变化趋势
Radical external beam radiotherapy for clinically localized prostate cancer in Japan: changing trends in the patterns of care process survey between 1996-1998 and 1999-2001.
作者信息
Ogawa Kazuhiko, Nakamura Katsumasa, Onishi Hiroshi, Sasaki Tomonari, Koizumi Masahiko, Shioyama Yoshiyuki, Komiyama Takafumi, Miyabe Yuuki, Teshima Teruki
机构信息
Department of Radiology, University of the Ryukyus, Okinawa, Japan.
出版信息
Anticancer Res. 2005 Sep-Oct;25(5):3507-11.
BACKGROUND
This report presents results of a study delineating changing trends in radical external beam radiotherapy usage for prostate cancer between the 1996-1998 and 1999-2001 Patterns of Care Study (PCS) survey periods in Japan.
MATERIALS AND METHODS
Out of the 694 patients comprising the 1996-1998 and 1999-2001 PCS surveys, the current study analyzed data for 444 patients with clinically localized prostate cancer treated with external beam radiotherapy (1996-1998 PCS: 161 patients; 1999-2001 PCS: 283 patients).
RESULTS
Significantly higher percentages of patients had earlier T stages (T1-T2: 48.2%) and well-differentiated tumors (23.6%) between 1999 and 2001 than between 1996 and 1998 (T1-T2: 34.6%, well-differentiated tumors: 15.1%). Although only 5.9% of patients were treated with radiotherapy by their own choice during 1996-1998, a larger proportion (26.5%) chose this treatment during 1999-2001. The median radiation dose was 65.0 Gy during 1996-1998, increasing to 68.4 Gy during 1999-2001. Moreover, the incidence of total treatment doses of > or = 70 Gy was higher during 1999-2001 (38.0%) than during 1996-1998 (17.5%). On the other hand, the percentage of patients receiving conformal therapy during 1996-1998 (49.1%) was almost the same as during 1999-2001 (50.2%). The median numbers of full-time equivalent (FTE) radiation oncologists increased in academic institutions (1.8 in 1996-1998; 2.4 in 1999-2001), while those in non-academic institutions remained low (0.5 in 1996-1998; 0.45 in 1999-2001).
CONCLUSION
In Japan, fewer prostate cancer patients treated with radical external beam radiotherapy had advanced diseases. Increasing percentages of patients chose radiotherapy and received increased radiation doses, which might reflect the growing acceptance of radical external beam radiotherapy as a first-line treatment for prostate cancer in Japan.
背景
本报告展示了一项研究的结果，该研究描绘了1996 - 1998年和1999 - 2001年日本癌症治疗模式研究（PCS）调查期间，前列腺癌根治性外照射放疗使用情况的变化趋势。
材料与方法
在1996 - 1998年和1999 - 2001年PCS调查的694例患者中，本研究分析了444例接受外照射放疗的临床局限性前列腺癌患者的数据（1996 - 1998年PCS：161例患者；1999 - 2001年PCS：283例患者）。
结果
1999年至2001年期间，T分期较早（T1 - T2：48.2%）和高分化肿瘤（23.6%）的患者比例显著高于1996年至1998年期间（T1 - T2：34.6%，高分化肿瘤：15.1%）。虽然在1996 - 1998年期间只有5.9%的患者自主选择放疗，但在1999 - 2001年期间这一比例更高（26.5%）。1996 - 1998年期间的中位放射剂量为65.0 Gy，在1999 - 2001年期间增加到68.4 Gy。此外，1999 - 2001年期间总治疗剂量≥70 Gy的发生率（38.0%）高于1996 - 1998年期间（17.5%）。另一方面，1996 - 1998年期间接受适形治疗的患者比例（49.1%）与1999 - 2001年期间（50.2%）几乎相同。学术机构中全职等效放疗肿瘤学家的中位数有所增加（1996 - 1998年为1.8；1999 - 2001年为2.4），而非学术机构中的这一数字仍然较低（1996 - 1998年为0.5；1999 - 2001年为0.45）。
结论
在日本，接受根治性外照射放疗的前列腺癌患者中晚期疾病患者较少。选择放疗的患者比例增加且接受的放射剂量增加，这可能反映出在日本根治性外照射放疗作为前列腺癌一线治疗方法的接受度不断提高。
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