在中国汉族人群中鉴定出一种新的HLA等位基因，DRB1*1609。

A novel HLA allele, DRB11609, identified in the Chinese Han population.

作者信息

Miao K R, Pan Q Q, Xue M, Zhou X Y, Fei X M, Tang Y H, Xu R, Zhang J W, Zhao X, Osowski L, Shi W X, Xu A L, Wang C Y, KuKuruga D

机构信息

The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiang Su Province, P.R. China.

出版信息

Tissue Antigens. 2005 Sep;66(3):248-50. doi: 10.1111/j.1399-0039.2005.00443.x.

DOI:10.1111/j.1399-0039.2005.00443.x

PMID:16101839

Abstract

A novel human leucocyte antigen-DRB116 (HLA-DRB116) allele (DRB11609) has been identified by sequencing-based typing (SBT) in Chinese Han population. This new allele has identical nucleotide sequence to DRB1160101 in exon 2, except for a single-nucleotide substitution from A to T at position 127. This change leads to an amino acid change from tyrosine to phenylalanin at residue 47 (Y47F). SBT was performed for cloned DRB116-specific polymerase chain reaction fragment. The serological phenotype of DRB11609 is equivalent to DR16 antigen.

摘要

通过基于测序的分型技术（SBT）在中国汉族人群中鉴定出一种新型人类白细胞抗原-DRB116（HLA-DRB116）等位基因（DRB11609）。该新等位基因在第2外显子中的核苷酸序列与DRB1160101相同，只是在第127位有一个从A到T的单核苷酸替换。这种变化导致第47位氨基酸从酪氨酸变为苯丙氨酸（Y47F）。对克隆的DRB116特异性聚合酶链反应片段进行了SBT检测。DRB11609的血清学表型等同于DR16抗原。