Samandary Sarah, Kridane-Miledi Hédia, Sandoval Jacqueline S, Choudhury Zareen, Langa-Vives Francina, Spencer Doran, Chentoufi Aziz A, Lemonnier François A, BenMohamed Lbachir
Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
UNITE INSERM 1016, Institut Cochin, Hôpital Saint-Vincent-de-Paul, 82, Avenue Denfert-Rochereau, 75674 Paris Cedex 14, France.
Hum Immunol. 2014 Aug;75(8):715-29. doi: 10.1016/j.humimm.2014.04.016. Epub 2014 May 4.
A significant portion of the world's population is infected with herpes simplex virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of diseases including genital herpes, oro-facial herpes, and the potentially blinding ocular herpes. While the global prevalence and distribution of HSV-1 and HSV-2 infections cannot be exactly established, the general trends indicate that: (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) over a half billion people worldwide are infected with HSV-2; (iii) the sub-Saharan African populations account for a disproportionate burden of genital herpes infections and diseases; (iv) the dramatic differences in the prevalence of herpes infections between regions of the world appear to be associated with differences in the frequencies of human leukocyte antigen (HLA) alleles. The present report: (i) analyzes the prevalence of HSV-1 and HSV-2 infections across various regions of the world; (ii) analyzes potential associations of common HLA-A, HLA-B and HLA-C alleles with the prevalence of HSV-1 and HSV-2 infections in the Caucasoid, Oriental, Hispanic and Black major populations; and (iii) discusses how our recently developed HLA-A, HLA-B, and HLA-C transgenic/H-2 class I null mice will help validate HLA/herpes prevalence associations. Overall, high prevalence of herpes infection and disease appears to be associated with high frequency of HLA-A(∗)24, HLA-B(∗)27, HLA-B(∗)53 and HLA-B(∗)58 alleles. In contrast, low prevalence of herpes infection and disease appears to be associated with high frequency of HLA-B(∗)44 allele. The finding will aid in developing a T-cell epitope-based universal herpes vaccine and immunotherapy.
世界上很大一部分人口感染了1型和/或2型单纯疱疹病毒（HSV-1和/或HSV-2），这些病毒会引发多种疾病，包括生殖器疱疹、口腔面部疱疹以及可能导致失明的眼部疱疹。虽然无法准确确定HSV-1和HSV-2感染的全球流行率和分布情况，但总体趋势表明：（i）HSV-1感染在全球比HSV-2更为普遍；（ii）全球超过5亿人感染了HSV-2；（iii）撒哈拉以南非洲人群承受着不成比例的生殖器疱疹感染和疾病负担；（iv）世界不同地区疱疹感染流行率的巨大差异似乎与人类白细胞抗原（HLA）等位基因频率的差异有关。本报告：（i）分析了世界各地区HSV-1和HSV-2感染的流行率；（ii）分析了常见的HLA-A、HLA-B和HLA-C等位基因与白种人、东方人、西班牙裔和黑人主要人群中HSV-1和HSV-2感染流行率之间的潜在关联；（iii）讨论了我们最近开发的HLA-A、HLA-B和HLA-C转基因/H-2 I类缺失小鼠将如何有助于验证HLA/疱疹流行率之间的关联。总体而言，疱疹感染和疾病的高流行率似乎与HLA-A(∗)24、HLA-B(∗)27、HLA-B(∗)53和HLA-B(∗)58等位基因的高频率有关。相比之下，疱疹感染和疾病的低流行率似乎与HLA-B(∗)44等位基因的高频率有关。这一发现将有助于开发基于T细胞表位的通用疱疹疫苗和免疫疗法。
