Gámez Pablo, Córdoba Mar, Ussetti Piedad, Carreño María C, Alfageme Fernando, Madrigal Luis, Nuñez José R, Calatayud Joaquín, Ramos Mercedes, Salas Clara, Varela Andrés
Thoracic Surgery Service, Hospital Universitario Puerta de Hierro, Madrid, Spain.
J Heart Lung Transplant. 2005 Aug;24(8):1098-102. doi: 10.1016/j.healun.2004.06.002.
There is currently no method for preservation and functional evaluation of clinical out-of-hospital non-heart-beating lung donors (NHBLD) that can be applied practically and systematically in clinical lung transplantation programs. A new method of preservation and functional evaluation of the lung has been developed in NHBLD that is based on the knowledge of various experimental studies. Initially, the viability of lungs harvested this way was proved from preliminary functional and histologic tests. In November 2002, we started using lung allografts from non-heart-beating donors. Five lung transplantations (4 bipulmonary and 1 unipulmonary) were performed successfully. The short and mid-term results have been excellent and all recipients are alive. We report our initial experience, which we hope will be of help to those involved in clinical lung transplantation programs worldwide.
目前，尚无一种能在临床肺移植项目中切实且系统应用的方法，用于对临床院外非心跳供肺者（NHBLD）的肺脏进行保存及功能评估。基于各项实验研究的知识，已开发出一种针对NHBLD的肺脏保存及功能评估新方法。最初，通过初步的功能和组织学检测，证实了以此方式获取的肺脏的存活能力。2002年11月，我们开始使用非心跳供者的肺脏进行同种异体移植。成功实施了5例肺移植手术（4例双肺移植和1例单肺移植）。短期和中期结果均非常出色，所有受者均存活。我们报告我们的初步经验，希望能对全球参与临床肺移植项目的人员有所帮助。
