Delgado Reynolds, Wadia Yasmin, Kar Biswajit, Ethridge Whitson, Zewail Aly, Pool Toni, Myers Timothy J, Scroggins Nancy, Frazier O H
Department of Cardiology, Texas Heart Institute, Houston, 77225, USA.
J Heart Lung Transplant. 2005 Aug;24(8):1166-70. doi: 10.1016/j.healun.2004.10.008.
Endogenous B-type natriuretic peptide (BNP) is thought to be produced in the cardiac ventricles. After sub-total cardiectomy and implantation of a total artificial heart (TAH), the abrupt withdrawal of BNP impairs renal function despite normal hemodynamic variables. We hypothesized that abrupt withdrawal of endogenous BNP may impair renal function and volume homeostasis and BNP may have a direct renal influence unrelated to its cardiovascular effect. Nesiritide infusion should be supplemented in the interim and weaned slowly until BNP levels normalize, which suggests that BNP is produced in tissues other than the cardiac ventricles.
