心脏电穿孔

Electroporation of the heart.

作者信息

Nikolski Vladimir P, Efimov Igor R

机构信息

Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.

出版信息

Europace. 2005 Sep;7 Suppl 2:146-54. doi: 10.1016/j.eupc.2005.04.011.

DOI:10.1016/j.eupc.2005.04.011

PMID:16102512

Abstract

Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According to the excitation theory of defibrillation, such shocks are aimed at depolarizing the membranes of most cardiac cells resulting in resynchronization of electrical activity in the heart. If shock-induced changes in transmembrane potential are large enough, they can cause transient tissue damage due to electroporation. In this review evidence is presented that (a) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field, and (b) electroporation can affect the outcome of defibrillation therapy; being both pro- and anti-arrhythmic.

摘要

除颤电击通常用于终止危及生命的心律失常。根据除颤的兴奋理论，此类电击旨在使大多数心脏细胞的膜去极化，从而导致心脏电活动重新同步。如果电击引起的跨膜电位变化足够大，它们可能会因电穿孔而导致短暂的组织损伤。在本综述中，有证据表明：（a）在临床相关强度的外部电场作用下，心脏组织可能会发生电穿孔；（b）电穿孔会影响除颤治疗的结果，既有促心律失常作用，也有抗心律失常作用。