Choudhary Muhammad I, Jalil Saima
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
Phytochemistry. 2005 Oct;66(19):2346-50. doi: 10.1016/j.phytochem.2005.06.023.
Natural products, longissiminone A (1) and longissiminone B (2), were isolated along with a known compound, glutinol (3), from a medicinal lichen, Usnea longissima. The structures of compounds 1 and 2 were determined with the help of spectroscopic studies. Compound 1 was found to possess potent anti-inflammatory activity in a cell-based contemporary assay. Cytotoxicity activity measured by cell viability assay showed 100% viability in the presence of 200 microg/mL conc. of these compounds.
从药用地衣长松萝中分离出天然产物长松萝醌A（1）和长松萝醌B（2），以及一种已知化合物谷甾醇（3）。借助光谱研究确定了化合物1和2的结构。在一项基于细胞的现代试验中发现化合物1具有强效抗炎活性。通过细胞活力测定法测得的细胞毒性活性表明，在这些化合物浓度为200微克/毫升时，细胞活力为100%。
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