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心脏瓣膜手术后患者的管理建议。

Recommendations for the management of patients after heart valve surgery.

作者信息

Butchart Eric G, Gohlke-Bärwolf Christa, Antunes Manuel J, Tornos Pilar, De Caterina Raffaele, Cormier Bertrand, Prendergast Bernard, Iung Bernard, Bjornstad Hans, Leport Catherine, Hall Roger J C, Vahanian Alec

机构信息

Department of Cardiothoracic Surgery, University Hospital of Wales, Cardiff, UK.

出版信息

Eur Heart J. 2005 Nov;26(22):2463-71. doi: 10.1093/eurheartj/ehi426. Epub 2005 Aug 15.

Abstract

Approximately 50,000 valve replacement operations take place in Europe annually and almost as many valve repair procedures. Previous European guidelines on management of patients after valve surgery were last published in 1995 and were limited to recommendations about antithrombotic prophylaxis. American guidelines covering the broader topic of the investigation and treatment of patients with valve disease were published in 1998 but devoted relatively little space to post-surgical management. This document represents the consensus view of a committee drawn from three European Society of Cardiology (ESC) Working Groups (WG): the WG on Valvular Heart Disease, the WG on Thrombosis, and the WG on Rehabilitation and Exercise Physiology. In almost all areas of patient management after valve surgery, randomized trials and meta-analyses do not exist. Such randomized trials as do exist are very few in number, are narrowly focused with small numbers, have limited general applicability, and do not lend themselves to meta-analysis because of widely divergent methodologies and different patient characteristics. Recommendations are therefore almost entirely based on non-randomized studies and relevant basic science.

摘要

欧洲每年约有50000例瓣膜置换手术,瓣膜修复手术数量与之相近。欧洲此前关于瓣膜手术后患者管理的指南最后一次发布于1995年,且仅限于抗血栓预防方面的建议。涵盖瓣膜病患者调查与治疗这一更广泛主题的美国指南于1998年发布,但对术后管理的篇幅相对较少。本文件代表了一个由欧洲心脏病学会(ESC)三个工作组(WG)组成的委员会的共识观点:心脏瓣膜病工作组、血栓形成工作组以及康复与运动生理学工作组。在瓣膜手术后患者管理的几乎所有领域,均不存在随机试验和荟萃分析。现有的此类随机试验数量极少,研究范围狭窄且样本量小,普遍适用性有限,并且由于方法差异很大和患者特征不同,不适合进行荟萃分析。因此,建议几乎完全基于非随机研究和相关基础科学。

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