Zhai Liang, Sun Fu-cheng, Jiang Ji-wei, Xiao Xiang-ling, Qian Xiao-ping, Wang Yi-kang, Yu Ren-kang, Xu Yong-jiang, Zhang Hong-feng
Dept. of Biomedical Engineering, Shanghai Jiaotong Univ.
Zhongguo Yi Liao Qi Xie Za Zhi. 2002 Jul;26(4):281-3, 280.
It has been a long time since ultrasound hyperthermia began to be used in the clinical management of cancers and benign diseases. Numerous biological and clinical investigations have demonstrated that: hyperthermia in the range of 41-45 degrees C can significantly enhance clinical response to radiation therapy and chemotherapy, and high-temperature hyperthermia (greater than 65 degrees C) alone is now being used as an alternative to conventional invasive surgery for selective tissue destruction, causing tumor coagulation and necrosis. As a promising noninvasive and effective local therapy, HIFU has attracted great attention. China is advanced in the clinical applications of HIFU. This article gives an introduction of the development and applications of ultrasound hyperthermia technology, and also provides a general review of a selection of ultrasound hyperthermia systems both in clinical use and under development.
自超声热疗开始应用于癌症及良性疾病的临床治疗以来,已经过去了很长时间。大量生物学和临床研究表明:41 - 45摄氏度范围内的热疗可显著增强对放射治疗和化疗的临床反应,而现在高温热疗(高于65摄氏度)单独作为一种选择性组织破坏的传统侵入性手术替代方法,可导致肿瘤凝固和坏死。作为一种有前景的非侵入性有效局部治疗方法,高强度聚焦超声(HIFU)已引起广泛关注。中国在HIFU临床应用方面处于领先地位。本文介绍了超声热疗技术的发展与应用,并对一些临床使用及正在研发的超声热疗系统进行了综述。