Abe M, Hiraoka M
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Apr;47(4):347-59.
Clinical researches in hyperthermia have recently expanded rapidly with the increase in our knowledge of the biological effects of heat on experimental systems. This article provides background information on the biological rationale and current status of technologies concerning thermometry and heating equipment for the application of hyperthermia to human cancer treatment. Much data has been accumulated recently in hyperthermia treatment with and without radiation to superficial tumours which are refractory to conventional treatments. In this paper the treatment results published recently have been surveyed. The complete responses of tumours treated by heat alone are in the range of 15 per cent as opposed to approximately 60 per cent for the combination of heat plus radiation. Clinical results so far published have demonstrated that local control is consistently better in the lesions treated with radiation plus heat than with radiation alone. The morbidity related to heat therapy is within tolerable limits. Several articles on the clinical results of deep-seated tumours treated by hyperthermia are reviewed. Problems to be solved in the application of heat to cancer therapy are discussed.
随着我们对热在实验系统中的生物学效应的认识不断增加，近年来热疗的临床研究迅速扩展。本文提供了有关热疗应用于人类癌症治疗的生物学原理以及温度测量和加热设备技术现状的背景信息。最近，在对传统治疗难治的浅表肿瘤进行热疗（无论是否联合放疗）方面已经积累了大量数据。本文对最近发表的治疗结果进行了调查。单独热疗治疗的肿瘤完全缓解率在15% 左右，而热疗加放疗联合治疗的完全缓解率约为60%。迄今为止发表的临床结果表明，放疗加温热治疗的病变局部控制始终优于单纯放疗。热疗相关的发病率在可耐受范围内。本文还综述了几篇关于深部肿瘤热疗临床结果的文章。讨论了热疗应用于癌症治疗中有待解决的问题。
