Chinetti-Gbaguidi Giulia, Fruchart Jean Charles, Staels Bart
UR 545 INSERM, Institut Pasteur de Lille, 1 rue Calmette BP245, 59019 Lille, France.
Curr Atheroscler Rep. 2005 Sep;7(5):396-401. doi: 10.1007/s11883-005-0053-x.
Fibrates are a widely used class of hypolipidemic drugs. The effects of fibrates are mediated through the activation of the transcription factor peroxisome proliferator-activated receptor a (PPARa). Fibrates act to modulate the transcription of genes that encode proteins controlling lipid transport and metabolism. Fibrates also exert pleiotropic anti-inflammatory effects by down regulating expression of genes encoding inflammatory cytokines and acute phase response proteins. These combined actions translate into clinical benefit as demonstrated by the reduction in cardiovascular morbidity and mortality in primary and secondary intervention trials.
贝特类药物是一类广泛使用的降血脂药物。贝特类药物的作用是通过激活转录因子过氧化物酶体增殖物激活受体α（PPARα）介导的。贝特类药物作用于调节编码控制脂质转运和代谢蛋白质的基因的转录。贝特类药物还通过下调编码炎性细胞因子和急性期反应蛋白的基因表达发挥多效抗炎作用。如在一级和二级干预试验中所证明的，这些联合作用转化为临床益处，表现为心血管发病率和死亡率的降低。
