Lebrun L, Pelletier G, Briantais M J, Brivet M, Khellaf A, Galanaud P
INSERM U 131, Hôpital A. Béclère, Clamart, France.
APMIS. 1992 Jun;100(6):531-4. doi: 10.1111/j.1699-0463.1992.tb00907.x.
The chemiluminescence (CL) response of normal peripheral blood polymorphonuclear cells (PMN) in ascitic fluids (cirrhotic = 32; malignant = 17) was studied independently of the ascitic fluid complement activity. CL response and fibronectin levels were higher in malignant ascitic fluid than in cirrhotic ascitic fluid (p less than 0.001). Addition of pure fibronectin or malignant ascitic fluids to cirrhotic ascitic fluids increased the CL response of normal PMN. These findings suggest that the susceptibility of cirrhotic patients to spontaneous bacterial peritonitis (SBP) is a multifactorial defect involving factors distinct from low C3 levels. Fibronectin is an important factor in the promotion of the respiratory burst of normal PMN stimulated by opsonized zymosan or PMA in ascitic fluid. Our results suggest that low levels of ascitic fluid fibronectin could partly explain the high susceptibility of cirrhotic patients to spontaneous bacterial peritonitis.
在不考虑腹水补体活性的情况下，对腹水（肝硬化腹水32例；恶性腹水17例）中正常外周血多形核白细胞（PMN）的化学发光（CL）反应进行了研究。恶性腹水的CL反应和纤连蛋白水平高于肝硬化腹水（p<0.001）。向肝硬化腹水中添加纯纤连蛋白或恶性腹水可增加正常PMN的CL反应。这些发现表明，肝硬化患者易患自发性细菌性腹膜炎（SBP）是一种多因素缺陷，涉及与低C3水平不同的因素。纤连蛋白是促进腹水调理酵母聚糖或佛波酯（PMA）刺激的正常PMN呼吸爆发的重要因素。我们的结果表明，腹水纤连蛋白水平低可能部分解释了肝硬化患者对自发性细菌性腹膜炎的高易感性。
