解析丙型肝炎病毒从基因组到功能的复制过程。

Unravelling hepatitis C virus replication from genome to function.

作者信息

Lindenbach Brett D, Rice Charles M

机构信息

Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

出版信息

Nature. 2005 Aug 18;436(7053):933-8. doi: 10.1038/nature04077.

DOI:10.1038/nature04077

PMID:16107832

Abstract

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.

摘要

自15多年前发现丙型肝炎病毒以来，科学家们竞相开发诊断方法、研究该病毒并寻找新的治疗方法。然而，几乎每一次剖析这种病原体的尝试都遇到了阻碍进展的障碍。它的复制仅限于人类或经实验感染的黑猩猩，直到最近，该病毒在细胞培养中的有效生长才得以实现。尽管如此，还是取得了来之不易的进展，首批抗病毒药物已进入临床试验阶段。