Wang Tianyu, Zhao Dengshuai, Zhang Yuanhang, Yu Dixi, Liu Guoping, Zhang Keshan
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan 528225, China.
College of Animal Science and Technology, Yangtze University, Jingzhou 434023, China.
Pathogens. 2024 Jul 4;13(7):564. doi: 10.3390/pathogens13070564.
Annexin A2 (ANXA2) is a multifunctional calcium- and phospholipid-binding protein that plays an important role in various cells. During pathogen infections, ANXA2 modulates the nuclear factor kappa-B (NF-κB) and cell apoptosis signaling pathways and guides the chemotaxis of inflammatory cells toward inflammation sites, thereby protecting the host organism through the modulation of the inflammatory response. In addition, ANXA2 can regulate immune responses, and in certain pathogen infections, it can interact with pathogen proteins to facilitate their invasion and proliferation. This review provides an overview of the research progress on how ANXA2 regulates pathogen infections.
膜联蛋白A2（ANXA2）是一种多功能的钙和磷脂结合蛋白，在多种细胞中发挥重要作用。在病原体感染期间，ANXA2调节核因子κB（NF-κB）和细胞凋亡信号通路，并引导炎症细胞向炎症部位趋化，从而通过调节炎症反应来保护宿主生物体。此外，ANXA2可以调节免疫反应，在某些病原体感染中，它可以与病原体蛋白相互作用以促进其入侵和增殖。本文综述了ANXA2如何调节病原体感染的研究进展。
