Prietsch V, Maier R, Schmitz L, Obladen M
Department of Neonatology, Universitätsklinikum Rudolf, Children's Hospital, Berlin, FRG.
Biol Neonate. 1992;61(3):142-9. doi: 10.1159/000243736.
Long-term variability (LTV) of heart rate was calculated continuously by a microprocessor in 25 preterm infants undergoing indomethacin treatment for closure of patent ductus arteriosus (PDA), in 24 preterm infants without signs of PDA, and in 10 neonates treated with prostaglandin E1 for cyanotic heart malformation. In infants with patent ductus arteriosus, LTV was lower than in controls. Following indomethacin, LTV increased most markedly (from 1.5 to 3.2; p less than 0.01) in infants with improved ventilation. The increase was less marked (from 1.8 to 2.5; p less than 0.05) in infants whose degree of respiratory failure did not change. LTV remained largely unchanged in infants who deteriorated. In 9 out of the 10 neonates treated with prostaglandin E1, LTV increased. We conclude that LTV corresponds to brain stem oxygenation and may be a useful tool to monitor treatment of PDA.
通过微处理器连续计算25例接受吲哚美辛治疗以关闭动脉导管未闭（PDA）的早产儿、24例无PDA体征的早产儿以及10例接受前列腺素E1治疗的青紫型先天性心脏病新生儿的心率长期变异性（LTV）。患有动脉导管未闭的婴儿的LTV低于对照组。吲哚美辛治疗后，通气改善的婴儿LTV增加最为显著（从1.5增至3.2；p<0.01）。呼吸衰竭程度未改变的婴儿LTV增加不明显（从1.8增至2.5；p<0.05）。病情恶化的婴儿LTV基本保持不变。在接受前列腺素E1治疗的10例新生儿中，有9例LTV增加。我们得出结论，LTV与脑干氧合作用相关，可能是监测PDA治疗的有用工具。
