一种用于测定端粒长度的改进方法及其在评估血液和唾液年龄中的应用。
An improved method for determining telomere length and its use in assessing age in blood and saliva.
作者信息
Lahnert Peter
机构信息
Department RNA-Chemie, Max-Delbrück-Centrum, Berlin, Germany.
出版信息
Gerontology. 2005 Sep-Oct;51(5):352-6. doi: 10.1159/000086374.
PMID:16110239
Abstract
BACKGROUND
It is disputed whether telomeres shorten with age.
OBJECTIVE
The proposition of this study was to answer this question.
METHODS
The question was answered by a simple method consisting of a color reaction combined with long-term electrophoresis and weak voltage.
RESULTS
The telomeres shorten and the shortening is much higher than previously assumed.
CONCLUSION
The telomere theory of ageing and cancer is corroborated and for the first time it is possible to estimate age in blood or saliva.
摘要
背景
端粒是否会随年龄增长而缩短存在争议。
目的
本研究旨在回答这一问题。
方法
通过一种简单方法回答该问题，该方法包括颜色反应、长期电泳和弱电压。
结果
端粒会缩短，且缩短程度比之前设想的要高得多。
结论
衰老和癌症的端粒理论得到证实，首次有可能在血液或唾液中估算年龄。
Zotero 插件