Villa A E, Fuster J M
Department of Psychiatry and Brain Research Institute, University of California, Los Angeles 90024.
Neuroreport. 1992 Jan;3(1):113-6. doi: 10.1097/00001756-199201000-00030.
The question is raised whether the sequence of spikes of a cortical neuron, i.e. its spike train, is related to cognitive functions. Neuronal patterns of firing in the inferotemporal cortex of monkeys performing visual delayed-matching tasks showed that short-term memory was accompanied by decreased bursting and changes in the incidence of recurrent spike-interval patterns. The temporal structure of the spike train suggests an inverse relationship between the incidence of repeated patterns and the degree of selectivity of sustained firing frequency elicited by the memorandum (sample stimulus).
由此引发了一个问题，即皮层神经元的尖峰序列，也就是其尖峰序列，是否与认知功能相关。在执行视觉延迟匹配任务的猴子颞下皮层中的神经元放电模式表明，短期记忆伴随着爆发性放电的减少以及重复尖峰间隔模式发生率的变化。尖峰序列的时间结构表明，重复模式的发生率与由记忆（样本刺激）引发的持续放电频率的选择性程度之间呈反比关系。
