[阿米啶和他克林（对阿尔茨海默病有效的药物）对单胺氧化酶A和B活性的影响]
[Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on the activity of monoamine oxidase A and B].
作者信息
Burov Iu V, Baĭmanov T D, Tat'ianenko L V, Sokolova N M, Tereshchenkova I M
出版信息
Biull Eksp Biol Med. 1992 Feb;113(2):149-50.
In vitro comparative studies of effects of amiridin (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopentane (b) choline monohydrate hydrochloride) and tacrine physostigmine and piracetam on monoamine oxidase A (MAO-A) and B (MAO-B) activity in the rat brain were carried out. Piracetam (1 x 10(-4)-1 x 10(-3) M) dose-dependently increased MAO-A and MAO-B activity. At all concentrations used (1 x 10(-7)-5 x 10(-4) M) physostigmine had no effect on MAO-A and MAO-B activity. Amiridin was found to inhibit MAO-B activity at 5 x 10(-4) M concentration only. Tacrine inhibited MAO-A activity at 5 x 10(-4) M concentration. The therapeutical effects of amiridin and tacrine in treatment of Alzheimer disease were not related to their action on MAO-A and -B activity.
开展了氨甲啶（9-氨基-2,3,5,6,7,8-六氢-1H-环戊烷[b]胆碱盐酸盐一水合物）、他克林、毒扁豆碱和吡拉西坦对大鼠脑单胺氧化酶A（MAO-A）和B（MAO-B）活性影响的体外比较研究。吡拉西坦（1×10⁻⁴ - 1×10⁻³ M）剂量依赖性地增加MAO-A和MAO-B活性。在所使用的所有浓度（1×10⁻⁷ - 5×10⁻⁴ M）下，毒扁豆碱对MAO-A和MAO-B活性均无影响。仅在5×10⁻⁴ M浓度下发现氨甲啶抑制MAO-B活性。他克林在5×10⁻⁴ M浓度下抑制MAO-A活性。氨甲啶和他克林在治疗阿尔茨海默病方面的治疗效果与其对MAO-A和 -B活性的作用无关。
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