Cherkasova T D, Iurkiv V A, Avrorov V P, Griboedov A V
Biull Eksp Biol Med. 1992 Feb;113(2):172-4.
Influence of intravenously administered to rats murine toxin of Y. pestis in the dose of I mg/ml (LD100) on the regulatory properties of heart plasma membranes adenylate cyclase (AC) has been studied during the intoxication. It has been shown that basal, fluoride,- and 5-guanylyl imidodiphosphate-stimulated AC activity remained unchanged during the intoxication. Stimulation of AC by isoproterenol, glucagon and histamine did not change during the first two hours and significantly decreased after 5 hours of intoxication. Affinity of AC for the investigated hormones did not change through the experiments.
研究了以1mg/ml（LD100）剂量静脉注射给大鼠的鼠疫耶尔森氏菌鼠毒素在中毒过程中对心脏质膜腺苷酸环化酶（AC）调节特性的影响。结果表明，中毒期间基础的、氟化物和5-鸟苷酰亚胺二磷酸刺激的AC活性保持不变。异丙肾上腺素、胰高血糖素和组胺对AC的刺激在最初两小时内没有变化，中毒5小时后显著降低。在整个实验过程中，AC对所研究激素的亲和力没有变化。
