Gibson J P, Bishop S C
The Institute for Genetics and Bioinformatics, University of New England, Armidale, NSW 2351, Australia.
Rev Sci Tech. 2005 Apr;24(1):343-53.
The improvement and utilisation of host genetic resistance to disease is an attractive option as a component of livestock disease control in a wide range of situations. This paper reviews the situations where genetic resistance of the host is likely to be a useful component of disease control and provides a framework for deciding whether genetic improvement of resistance is likely to be worthwhile. Discussion is focused on low-input production systems in the developing world, where disease resistance is particularly important. The authors propose an integrated strategy for the use of molecular markers in assessing genetic diversity and in utilising and improving host genetic resistance to disease. The integrated approach assures that there is value in the molecular genetic information whether or not it proves useful in genetic selection, a feature that should prove attractive to funding and executing agencies.
在多种情况下，提高和利用宿主对疾病的遗传抗性作为牲畜疾病控制的一个组成部分是一个有吸引力的选择。本文综述了宿主遗传抗性可能成为疾病控制有用组成部分的情况，并提供了一个框架，用于决定抗性的遗传改良是否可能值得。讨论聚焦于发展中世界的低投入生产系统，在这些系统中抗病性尤为重要。作者提出了一种综合策略，用于利用分子标记评估遗传多样性以及利用和提高宿主对疾病的遗传抗性。这种综合方法确保了分子遗传信息无论是否在遗传选择中证明有用都具有价值，这一特点应该会对资助和执行机构具有吸引力。
