Raez Luis E, Santos Edgardo S, Mudad Raja, Podack Eckhard R
Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, 1475 NW 12 Avenue, Miami, FL 33136, USA.
Expert Rev Anticancer Ther. 2005 Aug;5(4):635-44. doi: 10.1586/14737140.5.4.635.
Successful active immunotherapy is expected to be specific and nontoxic. Until now, the success of immunotherapy in cancer has been sporadic and unpredictable. This has been attributable in part to the lack of a full understanding of the mechanistic underpinnings of immune regulation. Furthermore, the lack of systematic success of immunotherapy, as argued in this review, stems from failing to effectively target tumors such as non-small cell lung cancer. In this review, the rationale and design for induction of immunity to non-small cell lung cancer and clinical trials of the most important lung cancer vaccines in development are discussed.
成功的主动免疫疗法有望具有特异性且无毒。到目前为止，免疫疗法在癌症治疗中的成功一直是零星且不可预测的。这部分归因于对免疫调节机制基础缺乏全面了解。此外，正如本综述所指出的，免疫疗法缺乏系统性成功源于未能有效靶向非小细胞肺癌等肿瘤。在本综述中，将讨论诱导针对非小细胞肺癌免疫的原理和设计以及正在研发的最重要肺癌疫苗的临床试验。
